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Paper A · Clinical psychopharmacology

Well on clozapine for 6 months, she stops smoking and starts nicotine patches. What happens to her clozapine level?

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Paper B

MRCPsych Paper B

Critical review of research, and clinical psychiatry across the specialties.

  • Critical review and research methods
  • General adult and old age psychiatry
  • Child and adolescent, substance misuse and forensic psychiatry
  • Learning disability and psychotherapy
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Paper A

Well on clozapine for 6 months, she stops smoking and starts nicotine patches. What happens to her clozapine level?

AFalls: the patches induce CYP1A2
BStays the same
CRises: smoke’s CYP1A2 induction wears off
DRises: nicotine was inhibiting CYP3A4
Not quite. The correct answer is C.

Tobacco smoke, not nicotine, induces CYP1A2. Once she stops, clozapine levels can rise sharply, and patches don’t prevent it.

Read the sourceSmoking and psychotropic drugsMaudsley Prescribing Guidelines (2025)

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Your pass covers Paper A and Paper B: every question with a worked explanation and the textbook source, two timed 150-question mock exams for each paper, smart revision that brings back what you got wrong, a readiness score and a week-by-week study plan to your sitting. Paid once, with no subscription and no automatic renewal.

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A study guide built from how much of the bank you have covered, your first-attempt accuracy, how well you hold on to what you have learnt and your timed mock exams. It appears after 50 questions across 3 topics. It is a study guide, not a prediction of your result.

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Is MRCPsych Prep affiliated with the Royal College of Psychiatrists?

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